Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity
| Autor: | Katrin H. Preller, Patricia Duerler, Brendan Adkinson, Philipp Stämpfli, Grega Repovs, Jie Lisa Ji, Joshua B. Burt, John D. Murray, John H. Krystal, Erich Seifritz, Alan Anticevic, Franz X. Vollenweider |
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| Přispěvatelé: | University of Zurich, Preller, Katrin H |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
610 Medicine & health Sensory system Biology Placebo Psilocybin 03 medical and health sciences 0302 clinical medicine Double-Blind Method medicine Humans Serotonin 2a Biological Psychiatry Brain Mapping Cross-Over Studies Functional connectivity Brain Crossover study 030104 developmental biology 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics Hallucinogens Serotonin Biological psychiatry 2803 Biological Psychiatry Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Biological Psychiatry. 88:197-207 |
| ISSN: | 0006-3223 |
| Popis: | Background The use of psilocybin in scientific and experimental clinical contexts has triggered renewed interest in the mechanism of action of psychedelics. However, its time-dependent systems-level neurobiology remains sparsely investigated in humans. Methods We conducted a double-blind, randomized, counterbalanced, crossover study comprising 23 healthy human participants who received placebo and 0.2 mg/kg of psilocybin orally on 2 different test days. Participants underwent magnetic resonance imaging at 3 time points between administration and peak effects: 20 minutes, 40 minutes, and 70 minutes after administration. Resting-state functional connectivity was quantified via a data-driven global brain connectivity method and compared with cortical gene expression maps. Results Psilocybin reduced associative, but concurrently increased sensory, brain-wide connectivity. This pattern emerged over time from administration to peak effects. Furthermore, we showed that baseline connectivity is associated with the extent of psilocybin-induced changes in functional connectivity. Lastly, psilocybin-induced changes correlated in a time-dependent manner with spatial gene expression patterns of the 5-HT2A (5-hydroxytryptamine 2A) and 5-HT1A (5-hydroxytryptamine 1A) receptors. Conclusions These results suggest that the integration of functional connectivity in sensory regions and the disintegration in associative regions may underlie the psychedelic state and pinpoint the critical role of the serotonin 2A and 1A receptor systems. Furthermore, baseline connectivity may represent a predictive marker of the magnitude of changes induced by psilocybin and may therefore contribute to a personalized medicine approach within the potential framework of psychedelic treatment. |
| Databáze: | OpenAIRE |
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