Effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis of randomized controlled trials

Autor:	Christian Mølgaard, Christian Ritz, Hanne Hauger, Mads Vendelbo Lind, Camilla T. Damsgaard, Rikke Pilmann Laursen
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty Adolescent medicine.medical_treatment Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Adolescents Placebo Gastroenterology law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Metabolic Diseases Randomized controlled trial law Internal medicine medicine Vitamin D and neurology Humans Vitamin D Child Children Cardiovascular risk factors Randomized Controlled Trials as Topic 030109 nutrition & dietetics Nutrition and Dietetics business.industry Insulin Vitamins medicine.disease chemistry Cardiovascular Diseases Dietary Supplements Randomized controlled trials Homeostatic model assessment Glycated hemoglobin medicine.symptom business
Zdroj:	Hauger, H, Laursen, R P, Ritz, C, Mølgaard, C, Lind, M V & Damsgaard, C T 2020, ' Effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis of randomized controlled trials ', European Journal of Nutrition, vol. 59, no. 3, pp. 873-884 . https://doi.org/10.1007/s00394-019-02150-x
ISSN:	1436-6215 1436-6207
Popis:	Purpose: In observational studies, higher S-25-hydroxyvitamin D [S-25(OH)D] has been associated with a more favorable cardiometabolic profile in childhood, but results may be confounded. We examined effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents. Methods: We systematically searched relevant databases for randomized controlled trials (RCTs) examining effects of vitamin D supplementation compared to placebo or a lower dose of vitamin D on blood glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), glycated hemoglobin, cholesterol [total, high-density, and low-density lipoprotein (LDL-C)], triglycerides, or blood pressure. We conducted random-effects meta-analyses of weighted mean differences in all participants and in subgroups of overweight/obese versus normal weight participants with or without baseline S-25(OH)D < 50 nmol/L. We also explored associations between responses in S-25(OH)D and outcomes by meta-regression. Results: Fourteen RCTs with a total of 1088 participants aged 4–19 years were included. In the meta-analysis, vitamin D supplementation increased S-25(OH)D by 27 nmol/L [95% CI 16; 37] (P < 0.0001) and increased LDL-C by 0.11 mmol/L [0.02; 0.20] (P = 0.02) without any subgroup differences and a generally low to moderate heterogeneity. Vitamin D supplementation had no other effects. However, in the meta-regression analysis, HOMA-IR decreased by 0.51 points [− 0.97; − 0.04] per 10 nmol/L increase in the endpoint S-25(OH)D among overweight/obese participants (P = 0.04). Conclusions: These results do not support the use of vitamin D supplementation for improving cardiometabolic health in childhood. Indicated beneficial effects on insulin resistance in those with obesity could be investigated further, while unfavorable effects on LDL-C may be a concern.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10aa2411c5a54cb03e534969eca0b70c https://doi.org/10.1007/s00394-019-02150-x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.