Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma
| Autor: | Barbara A. Torretti, Michael J. Coffey, Peter Mancuso |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Article Subject Adiponectin business.industry Leptin Population Adipose tissue Adipokine medicine.disease Obesity respiratory tract diseases Endocrinology Internal medicine Immunology medicine Immunology and Allergy Exhaled breath condensate education business hormones hormone substitutes and hormone antagonists Research Article Asthma |
| Zdroj: | Journal of Allergy |
| ISSN: | 1687-9791 1687-9783 |
| DOI: | 10.1155/2015/157919 |
| Popis: | Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims. Our hypothesis is that increased leptin and decreased adiponectin levels in obese subjects play a direct role in regulating inflammation in asthmatics. We wanted to examine the hypothesis that cysteinyl leukotrienes (cys-LT), inflammatory mediators that are regulated by adipokines, are involved in the pathogenesis of asthma. Methods. We studied a population of asthmatics and nonasthmatics, who in turn were divided into obese and nonobese categories. We examined leptin and its ratio to adiponectin, in asthmatics and nonasthmatics, with and without obesity. In addition, we measured cys-LT levels in exhaled breath condensate (EBC) and in peripheral blood monocytes (PBM) in these groups. Results. Leptin levels were increased in obese asthmatics compared to obese nonasthmatics. The leptin/adiponectin (L/A) ratio was higher in obese asthmatics compared to obese nonasthmatics. EBC cys-LT levels were elevated in asthmatics compared to nonasthmatics. Discussion. Proinflammatory adipokines, released from adipose tissue, may promote an asthma phenotype through enhanced cys-LT production that may result in more prevalent and difficult to control airway disease. |
| Databáze: | OpenAIRE |
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