Rare CBFB-MYH11 cryptic rearrangement in acute myeloid leukemia with ins(16)(p13.1q22q22)
| Autor: | Elizabeth Sagatys, Haipeng Shao, Hailing Zhang, Kenian Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Cbfb myh11
Genetics medicine.diagnostic_test CBFB-MYH11 Myeloid leukemia General Medicine Chimeric gene Biology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Molecular biology lcsh:RC254-282 Fusion gene AML FISH medicine MYH11 Fish ins (16) Gene Fluorescence in situ hybridization |
| Zdroj: | Advances in Modern Oncology Research, Vol 3, Iss 1, Pp 12-14 (2017) |
| ISSN: | 2424-7855 2424-7847 |
| Popis: | Acute myeloid leukemia (AML) with CBFB-MYH11 fusion gene is almost always associated with either inv(16)(p13.1q22) or t(16;16)(p13.1;q22). Only a few variants leading to formation of this chimeric gene have been reported. In this report, we describe a novel type of CBFB-MYH11 fusion variant generated by an insertion of CBFB into the MYH11 gene, which is identifiable by fluorescence in situ hybridization (FISH). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|