Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer
| Autor: | Jayaraman Selvakumar, Esther Y. Maier, Kuppuswamy Arumugam, Vincent M. Lynch, Stephanie Hufnagel, Jonathan F. Arambula, Sajal Sen, Jennie E. DeVore, Jonathan L. Sessler, Zhengrong Cui, Isaiah Aguilar |
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| Rok vydání: | 2020 |
| Předmět: |
Transplantation
Heterologous Antineoplastic Agents Immunogenic Cell Death 010402 general chemistry 01 natural sciences Biochemistry Article Catalysis Mice chemistry.chemical_compound Colloid and Surface Chemistry Immune system Coordination Complexes Heterocyclic Compounds In vivo Cell Line Tumor Neoplasms Animals Humans Redox active Inducer General Chemistry Endoplasmic Reticulum Stress In vitro 0104 chemical sciences Biomarker chemistry Cancer research Immunogenic cell death Gold Reactive Oxygen Species Methane Oxidation-Reduction Carbene |
| Zdroj: | J Am Chem Soc |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.0c09753 |
| Popis: | Immunogenic cell death (ICD) is a way of reengaging the tumor-specific immune system. ICD can be induced by treatment with chemotherapeutics. However, only a limited number of drugs and other treatment modalities have been shown to elicit the biomarker responses characteristic of ICD and to provide an anticancer benefit in vivo. Here, we report a rationally designed redox-active Au(I) bis-N-heterocyclic carbene that induces ICD both in vitro and in vivo. This work benefits from a synthetic pathway that allows for the facile preparation of asymmetric redox-active Au(I) bis-N-heterocyclic carbenes. |
| Databáze: | OpenAIRE |
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