Utility of Plasma Neurofilament Light in the 1Florida Alzheimer’s Disease Research Center (ADRC)
| Autor: | Maria T. Greig, Ranjan Duara, Rosemarie Rodriguez, Carlos Quinonez, Monica Rosselli, Todd E. Golde, Tatjana Rundek, Kevin Hanson, Nilufer Ertekin-Taner, Malek Adjouadi, Cesar L Chirinos, David A. Loewenstein, Miriam J. Rodriguez, Glenn E. Smith, Rosie E. Curiel Cid, Karen N. McFarland, David E. Vaillancourt, Steven T. DeKosky, Raquel Behar, Warren W. Barker, Michael Marsiske |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Oncology positron emission tomography diagnosis Disease Hippocampus plasma neurofilament light Cohort Studies hippocampal atrophy Cognition 0302 clinical medicine Neurofilament Proteins magnetic resonance imaging Medicine Aged 80 and over General Neuroscience Age Factors amyloid Brain Hispanic or Latino General Medicine Middle Aged Cognitive test Psychiatry and Mental health Clinical Psychology Cohort Female Alzheimer’s disease Research Article Lewy Body Disease medicine.medical_specialty White People Alzheimer's disease research 03 medical and health sciences Sex Factors Neuroimaging Alzheimer Disease Internal medicine Humans Cognitive Dysfunction Memory disorder Aged Amyloid beta-Peptides business.industry Dementia Vascular medicine.disease Black or African American Functional Status 030104 developmental biology Positron-Emission Tomography Etiology Atrophy Frontotemporal Lobar Degeneration Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Plasma NfL (pNfL) levels are elevated in many neurological disorders. However, the utility of pNfL in a clinical setting has not been established. Objective: In a cohort of diverse older participants, we examined: 1) the association of pNfL to age, sex, Hispanic ethnicity, diagnosis, and structural and amyloid imaging biomarkers; and 2) its association to baseline and longitudinal cognitive and functional performance. Methods: 309 subjects were classified at baseline as cognitively normal (CN) or with cognitive impairment. Most subjects had structural MRI and amyloid PET scans. The most frequent etiological diagnosis was Alzheimer’s disease (AD), but other neurological and neuropsychiatric disorders were also represented. We assessed the relationship of pNfL to cognitive and functional status, primary etiology, imaging biomarkers, and to cognitive and functional decline. Results: pNfL increased with age, degree of hippocampal atrophy, and amyloid load, and was higher in females among CN subjects, but was not associated with Hispanic ethnicity. Compared to CN subjects, pNfL was elevated among those with AD or FTLD, but not those with neuropsychiatric or other disorders. Hippocampal atrophy, amyloid positivity and higher pNfL levels each added unique variance in predicting greater functional impairment on the CDR-SB at baseline. Higher baseline pNfL levels also predicted greater cognitive and functional decline after accounting for hippocampal atrophy and memory scores at baseline. Conclusion: pNfL may have a complementary and supportive role to brain imaging and cognitive testing in a memory disorder evaluation, although its diagnostic sensitivity and specificity as a stand-alone measure is modest. In the absence of expensive neuroimaging tests, pNfL could be used for differentiating neurodegenerative disease from neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
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