Different Genotype Distribution of Human Papillomavirus between Cervical and Esophageal Cancers: A Study in Both High-Incidence Areas, Xinjiang, China
Autor: | Yage Fan, Yan Zeng, Limin Gao, Yi Zheng, Shiyu Liu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Risk 0301 basic medicine Oncology China medicine.medical_specialty Esophageal Neoplasms Genotype Article Subject Carcinogenesis Biopsy Uterine Cervical Neoplasms HPV vaccines Alphapapillomavirus Epithelium General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Cervical cancer Human papillomavirus 16 Intraepithelial neoplasia General Immunology and Microbiology business.industry Incidence Papillomavirus Infections HPV infection Cancer virus diseases General Medicine Middle Aged Esophageal cancer Uterine Cervical Dysplasia medicine.disease 030104 developmental biology Dysplasia 030220 oncology & carcinogenesis Carcinoma Squamous Cell Medicine Female business Research Article |
Zdroj: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
ISSN: | 2314-6141 2314-6133 |
Popis: | The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high-incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin-embedded esophageal tissues and 152 paraffin-embedded cervical tissues, respectively. The esophageal tissues include 40 normal epithelium (ENOR), 26 dysplasia (DYS), and 54 invasive squamous cell carcinoma (ESCC). The cervical tissues consisted of 40 normal epithelium (CNOR), 53 intraepithelial neoplasia (CIN), and 59 invasive squamous cell carcinoma (CSCC). Both esophageal and cervical tissues collected in this study came from the same area, in which both the ESCC and CSCC were in high incidence, Xinjiang province, China. HPV GenoArray test kits were served to analyze the HPV infection. The result shows that among the 59 CSCC tissues, the total infection rate of HPV was 98.3% (58/59). The positive rate of HPV-16 infection was 63.8% (37/58). It indicated that HPV-16 is the most common infection among all of the high-risk HPV. The multiple infection rate was 19.0% (11/58). Among the 54 ESCC, a total of 7 genotypes were detected. The total infection rate of HPV was 61.1% (33/54). The positive rate of HPV-16 infection was 63.6% (21/33). The multiple infection rate was 6.1% (2/33). Our result shows that high-risk-type HPV-16 was associated with both cervical cancer and esophageal cancer, which play a role in the high-incidence area in Xinjiang. We hope that our results could point out the direction for the treatment strategy of HPV-associated cancer, cervical cancer, and esophageal cancer and for the application of HPV vaccines in the future. |
Databáze: | OpenAIRE |
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