Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease

Autor:	Xueli Wang, Ashok Iyaswamy, Di Xu, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Yuncong Yang, Yinhui Li, Chen Chen, Min Li, Hung-Wing Li, Man Shing Wong
Rok vydání:	2022
Předmět:	General Materials Science
Zdroj:	ACS Applied Materials & Interfaces. 15:39-47
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.2c07859
Popis:	Oxidative stress, caused by an imbalance between the production and the accumulation of reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by aggregated amyloid-β (Aβ) in Alzheimer's disease (AD). Tools that can directly detect and monitor the presence and amount of Aβ-induced ROS are still lacking. We report herein the first Aβ-targeted ratiometric H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a16831c95e9763f43a3e4b6af2a733 https://doi.org/10.1021/acsami.2c07859 Zobrazit plný text záznamu