Planar Chiral Pseudo‐Isocoumarins by Copper Catalysed Desymmetrisation

Autor:	Adam J. Wright, Fiona J. McMartin, Liam G. Dyer, Lloyd H. Sayer, Philip C. Bulman Page, G. Richard Stephenson
Rok vydání:	2022
Předmět:	Inorganic Chemistry
Zdroj:	European Journal of Inorganic Chemistry. 2022
ISSN:	1099-0682 1434-1948
DOI:	10.1002/ejic.202100841
Popis:	A new copper catalysed desymmetrisation reaction of bisalkynyl ferrocenecarboxylic acids results in the first asymmetric synthesis of planar chiral pseudo-isocoumarins in up to 64 % enantiomeric excess and up to 99 % yield. The absolute configuration of the chiral heterocycles is proven by chemical correlation and circular dichroism spectroscopy, opening the way for the rational extension of this method to produce bioactive isocoumarin-fused ferrocene derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109f7d445a1bfc930a3d4e39051b6138 https://doi.org/10.1002/ejic.202100841 Zobrazit plný text záznamu