| Autor: |
Frank G. Ondrey, Lee W. Wattenberg, Vernon E. Steele, Jennifer D. Antonides, Beverly R. Wuertz, Donna E. Seabloom, Arthur R. Galbraith |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1940-6207.c.6547108 |
| Popis: |
Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in the treatment of asthma, were evaluated to determine their individual and combinational chemopreventive efficacy on benzo(a)pyrene-induced lung tumors in female A/J mice. Nicotinamide fed at a dietary concentration of 0.75% significantly inhibited tumor multiplicity. Nicotinamide by aerosol inhalation at doses up to 15 mg/kg/day did not result in a statistically significant reduction in tumor multiplicity. Finally, dietary nicotinamide was administered with aerosol budesonide and tumor multiplicity reduced by 90% at 1 week and 49% at 8 weeks post last carcinogen dose. We conclude nicotinamide is an effective and safe agent for lung cancer dietary prevention at both early- and late-stage carcinogenesis and that efficacy is increased with aerosol budesonide. Combination chemoprevention with these agents is a well-tolerated and effective strategy which could be clinically advanced to human studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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