Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes
| Autor: | Esther M.M. Van Lieshout, Peter Patka, M.W.G.A. Bronkhorst |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Complications Innate immune system trauma business.industry Public health Single-nucleotide polymorphism medicine.disease Article infection Sepsis Systemic inflammatory response syndrome systemic inflammatory response syndrome TLR2 single nucleotide polymorphism Infectious disease (medical specialty) genetic variation Immunology medicine business Multiple organ dysfunction syndrome multiple organ dysfunction syndrome |
| Zdroj: | The Open Orthopaedics Journal |
| ISSN: | 1874-3250 |
| Popis: | Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe trauma patients. We describe a trauma patient with multiple infectious complications caused by multiple micro-organisms leading to prolonged hospital stay with numerous treatments. This patient had multiple single nucleotide polymorphisms (SNPs) in the MBL2, MASP2, FCN2 and TLR2 genes, most likely contributing to increased susceptibility and severity of infectious disease. |
| Databáze: | OpenAIRE |
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