Catalytic Enantioselective Reductive Cross Coupling of Electron-Deficient Olefins
Autor: | Kangning Cao, Chunyang Li, Dong Tian, Xiaowei Zhao, Yanli Yin, Zhiyong Jiang |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Organic Letters. 24:4788-4792 |
ISSN: | 1523-7052 1523-7060 |
Popis: | We report an enantioselective reductive cross coupling of electron-deficient olefins. Using a visible-light-driven cooperative photoredox and chiral Brønsted acid-catalyzed reaction with a Hantzsch ester as the terminal reductant, various cyclic and acyclic enones with 2-vinylpyridines were converted in high yields (up to 93%) to a wide range of enantioenriched pyridine derivatives featuring diverse γ-tertiary carbon stereocenters with good to excellent enantioselectivities (up to99% ee). |
Databáze: | OpenAIRE |
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