Catalytic Enantioselective Reductive Cross Coupling of Electron-Deficient Olefins

Autor:	Kangning Cao, Chunyang Li, Dong Tian, Xiaowei Zhao, Yanli Yin, Zhiyong Jiang
Rok vydání:	2022
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:4788-4792
ISSN:	1523-7052 1523-7060
Popis:	We report an enantioselective reductive cross coupling of electron-deficient olefins. Using a visible-light-driven cooperative photoredox and chiral Brønsted acid-catalyzed reaction with a Hantzsch ester as the terminal reductant, various cyclic and acyclic enones with 2-vinylpyridines were converted in high yields (up to 93%) to a wide range of enantioenriched pyridine derivatives featuring diverse γ-tertiary carbon stereocenters with good to excellent enantioselectivities (up to99% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1098c9664062f1f4bcb3e1fa82339b62 https://doi.org/10.1021/acs.orglett.2c01801 Zobrazit plný text záznamu