Cancer Stemness in Apc- vs. Apc/KRAS-Driven Intestinal Tumorigenesis

Autor:	Yaser Atlasi, Ron Smits, Riccardo Fodde, Andreas Kremer, Sabrina Roth, Pieter Sonneveld, Andrea Sacchetti, Mehrnaz Ghazvini, Patrick Franken, Rosalie Joosten
Přispěvatelé:	Developmental Biology, Pathology, Gastroenterology & Hepatology
Rok vydání:	2013
Předmět:	Genes APC Intracellular Space lcsh:Medicine Mice Transgenic Biology medicine.disease_cause Immunophenotyping Mice SDG 3 - Good Health and Well-being Cancer stem cell Intestinal Neoplasms medicine Animals Cluster Analysis lcsh:Science Antigen-presenting cell beta Catenin Multidisciplinary Integrin beta1 lcsh:R LGR5 Wnt signaling pathway CD24 Antigen medicine.disease Gene Expression Regulation Neoplastic Disease Models Animal Cell Transformation Neoplastic Genes ras medicine.anatomical_structure Mutation Paneth cell Immunology Neoplastic Stem Cells Cancer research Adenocarcinoma lcsh:Q KRAS Stem cell Transcriptome Signal Transduction Research Article
Zdroj:	PLoS One (print), 8(9). Public Library of Science PLoS ONE, Vol 8, Iss 9, p e73872 (2013) PLoS ONE
ISSN:	1932-6203
Popis:	Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc/KRAS-mutant intestinal tumours. Whereas CSCs are present in Apc/KRAS tumours, they appear to be very rare (
Databáze:	OpenAIRE
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