Pubertal outcome in a female with virilizing adrenocortical carcinoma
| Autor: | Sharon E. Oberfield, James Garvin, Hanina Hibshoosh, Emily Breidbart, Tamara Cameo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Urology Malignancy Article 03 medical and health sciences 0302 clinical medicine Endocrinology 030225 pediatrics medicine Adrenocortical Carcinoma Adrenocortical carcinoma Endocrine system Humans Gynecology Menarche business.industry Virilization Adrenarche Puberty Adrenalectomy Androgen medicine.disease Prognosis Virilism Pubic hair Adrenal Cortex Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 29(4) |
| ISSN: | 2191-0251 |
| Popis: | Adrenocortical tumors are neoplasms that rarely occur in pediatric patients. Adrenocortical carcinoma (ACC) is even more uncommon, and is an aggressive malignancy with 5-year survival of 55% in a registry series. There is a lack of information on long-term endocrine outcome in survivors. We describe a 10-year follow-up in a patient who presented at 3 years 5 months with a 1-year history of axillary odor and 6 months’ history of pubic hair development with an increased clitoral size. Androgen levels were increased and a pelvic sonogram revealed a suprarenal mass of the left kidney. The tumor was successfully removed. At 6 years 11 months, androgen levels increased again. Workup for tumor recurrence was negative and the findings likely represented early adrenarche. The patient had menarche at an appropriate time and attained a height appropriate for her family. |
| Databáze: | OpenAIRE |
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