Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography

Autor: Ralph Sinkus, Gwenaël Pagé, Valérie Vilgrain, Gaspard d’Assignies, Philippe Garteiser, Helena S. Leitão, Bernard E. Van Beers
Přispěvatelé: Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Ralph, Sinkus, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Cirrhosis
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Science
Imaging techniques
Article
030218 nuclear medicine & medical imaging
Shear modulus
03 medical and health sciences
0302 clinical medicine
Magnetic resonance imaging
Hepatitis B
Chronic
Imaging
Three-Dimensional
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Internal medicine
[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
medicine
Humans
Aged
Hepatitis
Multidisciplinary
medicine.diagnostic_test
Hepatology
business.industry
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Diagnostic markers
Hepatitis C
Chronic
Middle Aged
medicine.disease
Confidence interval
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
3. Good health
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Medicine
Elasticity Imaging Techniques
030211 gastroenterology & hepatology
Female
Elastography
business
Viral hepatitis
Nuclear medicine
Zdroj: Scientific Reports
Scientific Reports, 2021, 11, pp.19386. ⟨10.1038/s41598-021-98726-x⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Nature Publishing Group, 2021, 11, pp.19386. ⟨10.1038/s41598-021-98726-x⟩
ISSN: 2045-2322
Popis: The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56 Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. The multifrequency dispersion coefficient had the largest AUC for necro-inflammatory activity A ≥ 2 [0.84 (0.71–0.93) vs. storage modulus AUC: 0.65 (0.50–0.79), p = 0.03], whereas the storage modulus had the largest AUC for fibrosis F ≥ 2 [AUC (95% confidence intervals) 0.91 (0.79–0.98)] and cirrhosis F4 [0.97 (0.88–1.00)]. The measurement of the multifrequency dispersion coefficient at three-dimensional MR elastography has the potential to grade liver necro-inflammation in patients with chronic vial hepatitis.
Databáze: OpenAIRE
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