The impact of visceral and general obesity on vascular and left ventricutar function and geometry: a cross-sectional magnetic resonance imaging study of the UK Biobank
| Autor: | Jos J.M. Westenberg, Max J P van Hout, Hildo J. Lamb, Martin J. Schalij, Ilona A. Dekkers, Arthur J.H.A. Scholte |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cardiac function curve Cardiac output Left ventricular geometry Population Adipose tissue Geometry Body fat distribution 030204 cardiovascular system & hematology Body fat percentage Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Magnetic resonance imaging medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Obesity education Adiposity Aged Biological Specimen Banks education.field_of_study Ejection fraction medicine.diagnostic_test business.industry Left ventricular function Original Articles General Medicine Middle Aged United Kingdom Editor's Choice Cross-Sectional Studies Visceral adipose tissue Female Cardiology and Cardiovascular Medicine business Bioelectrical impedance analysis |
| Zdroj: | European Heart Journal-Cardiovascular Imaging, 21(3), 273-281. OXFORD UNIV PRESS European Heart Journal Cardiovascular Imaging |
| Popis: | Aims We aimed to evaluate the associations of body fat distribution with cardiovascular function and geometry in the middle-aged general population. Methods and results Four thousand five hundred and ninety participants of the UK Biobank (54% female, mean age 61.1 ± 7.2 years) underwent cardiac magnetic resonance for assessment of left ventricular (LV) parameters [end-diastolic volume (EDV), ejection fraction (EF), cardiac output (CO), and index (CI)] and magnetic resonance imaging for body composition analysis [subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT)]. Body fat percentage (BF%) was assessed by bioelectrical impedance. Linear regressions were performed to assess the impact of visceral (VAT) and general (SAT and BF%) obesity on cardiac function and geometry. Visceral obesity was associated with a smaller EDV [VAT: β −1.74 (−1.15 to −2.33)], lower EF [VAT: β −0.24 (−0.12 to −0.35), SAT: β 0.02 (−0.04 to 0.08), and BF%: β 0.02 (−0.02 to 0.06)] and the strongest negative association with CI [VAT: β −0.05 (−0.06 to −0.04), SAT: β −0.02 (−0.03 to −0.01), and BF% β −0.01 (−0.013 to −0.007)]. In contrast, general obesity was associated with a larger EDV [SAT: β 1.01 (0.72–1.30), BF%: β 0.37 (0.23–0.51)] and a higher CO [SAT: β 0.06 (0.05–0.07), BF%: β 0.02 (0.01–0.03)]. In the gender-specific analysis, only men had a significant association between VAT and EF [β −0.35 (−0.19 to −0.51)]. Conclusion Visceral obesity was associated with a smaller LV EDV and subclinical lower LV systolic function in men, suggesting that visceral obesity might play a more important role compared to general obesity in LV remodelling. |
| Databáze: | OpenAIRE |
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