Synthesis of a Macrocycle Based on Linked Amino Acid Mimetics (LAAM)

Autor: Diana V. Martin, David Maxwell, Basvoju A. Bhanu Prasad, Duoli Sun, Zhenghong Peng, William G. Bornmann
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Popis: We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAM's). Macrocycles based on the LAAM concept provide both a peptide targeting region and two independently variable functional regions. In the prototype structure, the commonly known Arg-Gly-Asp (RGD) sequence was used for the targeting region. The functional regions contain a phenyl group, and the linkage was formed via a Ring-Closing Metathesis (RCM) reaction.
Databáze: OpenAIRE
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