Synthesis of a Macrocycle Based on Linked Amino Acid Mimetics (LAAM)
Autor: | Diana V. Martin, David Maxwell, Basvoju A. Bhanu Prasad, Duoli Sun, Zhenghong Peng, William G. Bornmann |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: | |
Popis: | We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAM's). Macrocycles based on the LAAM concept provide both a peptide targeting region and two independently variable functional regions. In the prototype structure, the commonly known Arg-Gly-Asp (RGD) sequence was used for the targeting region. The functional regions contain a phenyl group, and the linkage was formed via a Ring-Closing Metathesis (RCM) reaction. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.