Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain

Autor:	Rolandas Zakelis, Basant K Bajpai, Mantas Deimantavicius, Daiva Imbrasiene
Přispěvatelé:	MDPI AG (Basel, Switzerland)
Rok vydání:	2020
Předmět:	Materials science Correlation coefficient PRx = pressure reactivity index CA = cerebrovascular autoregulation Blood volume Cerebral autoregulation Article lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Linear regression lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry CBF = cerebral blood flow VRx = volumetric reactivity index business.industry ICP = intracranial pressure General Neuroscience Attenuation Ultrasound ABP = arterial blood pressure CPP = cerebral perfusion pressure TOF = time-of-flight 030208 emergency & critical care medicine Confidence interval Ultrasonic sensor business 030217 neurology & neurosurgery Biomedical engineering
Zdroj:	Brain Sciences Brain Sciences, Vol 10, Iss 205, p 205 (2020) Brain Sciences; Volume 10; Issue 4; Pages: 205 Brain sciences, Basel : MDPI, 2020, vol. 10, iss. 4, art. no. 205, p. 1-12
ISSN:	2076-3425
Popis:	This is a comparative study of two novel noninvasive cerebrovascular autoregulation (CA) monitoring methods based on intracranial blood volume (IBV) changes in the human brain. We investigated the clinical applicability of the new volumetric reactivity index (VRx2), reflected by intracranial ultrasonic attenuation dynamics for noninvasive CA monitoring. The CA was determined noninvasively on 43 healthy participants by calculating the volumetric reactivity index (VRx1 from time-of-flight of ultrasound, VRx2 from attenuation of ultrasound). The VRx was calculated as a moving correlation coefficient between the arterial blood pressure and noninvasively measured IBV slow waves. Linear regression between VRx1 and VRx2 (averaged per participants) showed a significant correlation (r = 0.731, p < 0.0001, 95% confidence interval [0.501–0.895]) in data filtered by bandpass filtering. On the other hand, FIR filtering demonstrated a slightly better correlation (r = 0.769, p < 0.0001, 95% confidence interval [0.611–0.909]). The standard deviation of the difference by bandpass filtering was 0.1647 and bias −0.3444; and by FIR filtering 0.1382 and bias −0.3669. This comparative study showed a significant coincidence of the VRx2 index compared to that of VRx1. Hence, VRx2 could be used as an alternative, cost-effective noninvasive cerebrovascular autoregulation index in the same way as VRx1 values are used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108faeac2bfe0d44ff3c3438b51489c9 https://pubmed.ncbi.nlm.nih.gov/32244750 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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