Use of Acular LS in the pain management of keratoconus: a pilot study
| Autor: | Ralph E. Gundel, Jessica O. Yu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Keratoconus medicine.medical_specialty genetic structures Contact Lenses medicine.medical_treatment Pain Pilot Projects Placebo Ketorolac Tromethamine Drug Administration Schedule Surveys and Questionnaires medicine Humans Aged Analysis of Variance business.industry Anti-Inflammatory Agents Non-Steroidal Palliative Care Repeated measures design Small sample Pain management Middle Aged medicine.disease eye diseases Ophthalmology Artificial tears Treatment Outcome Inclusion and exclusion criteria Physical therapy Female sense organs Ophthalmic Solutions business Optometry Follow-Up Studies |
| Zdroj: | Optometry and vision science : official publication of the American Academy of Optometry. 87(2) |
| ISSN: | 1538-9235 |
| Popis: | Purpose. The purpose of this pilot study was to determine the efficacy of ketorolac tromethamine 0.4% for pain management in conjunction with rigid gas permeable contact lenses in keratoconus. Any potential side effects and complications of this application were examined. Methods. A total of 12 current keratoconus patients who were presently experiencing discomfort or pain associated with their rigid gas permeables for keratoconus and/or who were contact lens-intolerant were identified from the existing patient population at the SUNY University Optometric Center. Symptomatic subjects were identified through positive feedback to a study Inclusion Questionnaire mailed to their homes. Subjects were treated on the basis of each eye separately in a modified monocular trial that spanned 5 weeks. After establishing that all inclusion and exclusion criteria were met, subjects were instructed to first use an unlabeled bottle of artificial tear solution (placebo) for 2 weeks, and then an unmarked bottle of ketorolac tromethamine 0.4% for 2 weeks in the designated eye. One drop was instilled twice a day, and the eye not assigned to take the drops served as the control. Subjects were monitored through weekly follow-up visits and repeated Keratoconus Symptom and Severity Questionnaires. Results. Responses from the Keratoconus Symptom and Severity Questionnaire were analyzed using a 2-factor Repeated Measures Analysis of Variance. Among the small subject subset, there was no statistically significant predilection for the ketorolac tromethamine 0.4% in managing the discomfort and pain associated with keratoconus. The artificial tear solution appeared to be equally effective in improving comfort. Conclusions. There was no conclusive result as to the efficacy of the ketorolac tromethamine 0.4% vs. the artificial tear solution in the pain management of keratoconus. This could be attributed to a number of physiological and situational factors, as well as small sample size. (Optom Vis Sci 2010;87:1–●●●) |
| Databáze: | OpenAIRE |
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