A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients
Autor: | Kamal Eldin Ahmed Abdelsalam, Syed Mohammed Basheeruddin Asdaq, Mohammed Asad, Wael Ahmed Alharbi, Yahya Mohzari, Ahmed A. Alrashed, Kholoud Nasser Alrami, NajwaJilan Alghamdi, Monjid Ahmed Ibrahim Ahmed |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Breast Neoplasms melatonin Gastroenterology Breast Neoplasms Male Melatonin GABA 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Humans Medicine epinephrine skin and connective tissue diseases 030304 developmental biology 0303 health sciences business.industry Communication Incidence (epidemiology) Public Health Environmental and Occupational Health Case-control study Cancer medicine.disease serotonin Cross-Sectional Studies Epinephrine Case-Control Studies ghrelin 030220 oncology & carcinogenesis Male breast cancer Female Ghrelin dopamine business Biomarkers medicine.drug |
Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 4852, p 4852 (2021) International Journal of Environmental Research and Public Health |
ISSN: | 1660-4601 |
DOI: | 10.3390/ijerph18094852 |
Popis: | The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels. |
Databáze: | OpenAIRE |
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