A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients

Autor: Kamal Eldin Ahmed Abdelsalam, Syed Mohammed Basheeruddin Asdaq, Mohammed Asad, Wael Ahmed Alharbi, Yahya Mohzari, Ahmed A. Alrashed, Kholoud Nasser Alrami, NajwaJilan Alghamdi, Monjid Ahmed Ibrahim Ahmed
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Environmental Research and Public Health, Vol 18, Iss 4852, p 4852 (2021)
International Journal of Environmental Research and Public Health
ISSN: 1660-4601
DOI: 10.3390/ijerph18094852
Popis: The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels.
Databáze: OpenAIRE