Hypertrophy, Hyperplasia, and Infectious Virus in Gut‐Associated Lymphoid Tissue of Mice after Oral Inoculation with Simian‐Human or Bovine‐Human Reassortant Rotaviruses
| Autor: | Charlotte A. Moser, H Fred Clark, Douglas V. Dolfi, Paul A. Offit, Matthew L. Di Vietro, Penny Heaton |
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| Rok vydání: | 2001 |
| Předmět: |
Rotavirus
Lymphoid Tissue viruses Gut-associated lymphoid tissue Administration Oral Viral Plaque Assay Biology medicine.disease_cause Lymphoid hyperplasia Virus Mice Peyer's Patches medicine Animals Humans Immunology and Allergy Mesenteric lymph nodes Mesentery Mice Inbred BALB C Hyperplasia Peyer's patch Viral Vaccines Haplorhini Hypertrophy Organ Size medicine.disease Virology Intestines Infectious Diseases medicine.anatomical_structure Lymphatic system Cattle Electrophoresis Polyacrylamide Gel Female medicine.symptom Intussusception Reassortant Viruses |
| Zdroj: | The Journal of Infectious Diseases. 183:1108-1111 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/319294 |
| Popis: | Oral inoculation of infants with a vaccine that contains simian-human reassortant rotaviruses has been found to be a rare cause of intussusception. Because intussusception can be associated with enlargement of gut-associated lymphoid tissue, we studied the capacity of simian-human and bovine-human reassortant rotaviruses to cause lymphoid hypertrophy and hyperplasia of Peyer's patches (PP) of adult BALB/c mice. Neither hypertrophy nor hyperplasia was detected in PP after oral inoculation with simian-human or bovine-human reassortant rotaviruses. However, infectious virus was detected in PP and mesenteric lymph nodes after oral inoculation with simian, but not bovine, reassortant rotaviruses. Implications of these findings on the pathogenesis of intussusception are discussed. |
| Databáze: | OpenAIRE |
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