Lung function, percent emphysema, and QT duration: The Multi-Ethnic Study of Atherosclerosis (MESA) lung study

Autor: Matthew J. Budoff, Susan R. Heckbert, W. Craig Johnson, R. Graham Barr, Elsayed Z. Soliman, Eric A. Hoffman, Karol E. Watson, Gina S. Lovasi, John H.M. Austin, Bruce M. Psaty, Jerry A. Krishnan, Hilary F. Armstrong
Rok vydání: 2017
Předmět:
Male
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Vital Capacity
Population
030204 cardiovascular system & hematology
Sensitivity and Specificity
QT interval
Article
Electrocardiography
Pulmonary Disease
Chronic Obstructive
03 medical and health sciences
FEV1/FVC ratio
Sex Factors
0302 clinical medicine
Forced Expiratory Volume
Internal medicine
Heart rate
medicine
Humans
Prospective Studies
cardiovascular diseases
education
Aged
Aged
80 and over
education.field_of_study
COPD
Framingham Risk Score
Lung
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
United States
respiratory tract diseases
Long QT Syndrome
medicine.anatomical_structure
Pulmonary Emphysema
030228 respiratory system
Cardiology
Female
Tomography
X-Ray Computed
business
circulatory and respiratory physiology
Zdroj: Respiratory Medicine. 123:1-7
ISSN: 0954-6111
Popis: Background The QT interval on electrocardiogram (ECG) reflects ventricular repolarization; a prolonged QT interval is associated with increased mortality risk. Prior studies suggest an association between chronic obstructive pulmonary disease (COPD) and prolonged QT interval. However, these studies were small and often enrolled hospital-based samples. We tested the hypotheses that lower lung function and increased percent emphysema on computed tomography (CT) are associated with a prolonged QT interval in a general population sample and additionally in those with COPD. Methods As part of the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study, we assessed spirometry, full-lung CT scans, and ECGs in participants aged 45–84 years. The QT on ECGs was corrected for heart rate (QTc) using the Framingham formula. QTc values = 460 msec in women and ≥450 msec in men were considered abnormal (prolonged QT C ). Multivariate regression models were used to examine the cross-sectional association between pulmonary measures and QT C. Results The mean age of the sample of 2585 participants was 69 years, and 47% were men. There was an inverse association between FEV 1 %, FVC%, FEV 1 /FVC%, emphysema, QTc duration and prolonged QTc. Gender was a significant interaction term, even among never smokers. Having severe COPD was also associated with QTc prolongation. Conclusions Our analysis revealed a significant association between lower lung function and longer QTc in men but not in women in a population-based sample. Our findings suggest the possibility of gender differences in the risk of QTc-associated arrhythmias in a population-based sample.
Databáze: OpenAIRE
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