Evidence for a causal link between sepsis and long-term mortality:a systematic review of epidemiologic studies
| Autor: | Andrew J. I. Jones, Viyaasan Mahalingasivam, Gordon D. Rubenfeld, Manu Shankar-Hari, Kathryn M Rowan, Michael Ambler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Confounding Factors (Epidemiology) Resuscitation Population MEDLINE Critical Care and Intensive Care Medicine Sepsis 03 medical and health sciences 0302 clinical medicine Bias Confounding factors (epidemiology) Internal medicine Epidemiology medicine Humans Hospital Mortality 030212 general & internal medicine Mortality Intensive care medicine education education.field_of_study business.industry Septic shock Research Hazard ratio Confounding 030208 emergency & critical care medicine medicine.disease Patient Discharge Causality Epidemiologic Studies Treatment Outcome business |
| Zdroj: | Shankar-Hari, M, Ambler, M, Mahalingasivam, V, Jones, A, Rowan, K & Rubenfeld, G D 2016, ' Evidence for a causal link between sepsis and long-term mortality : a systematic review of epidemiologic studies ', CRITICAL CARE, vol. 20, no. 1, pp. 101 . https://doi.org/10.1186/s13054-016-1276-7 Critical Care |
| DOI: | 10.1186/s13054-016-1276-7 |
| Popis: | Background In addition to acute hospital mortality, sepsis is associated with higher risk of death following hospital discharge. We assessed the strength of epidemiological evidence supporting a causal link between sepsis and mortality after hospital discharge by systematically evaluating the available literature for strength of association, bias, and techniques to address confounding. Methods We searched Medline and Embase using the following ‘mp’ terms, MESH headings and combinations thereof - sepsis, septic shock, septicemia, outcome. Studies published since 1992 where one-year post-acute mortality in adult survivors of acute sepsis could be calculated were included. Two authors independently selected studies and extracted data using predefined criteria and data extraction forms to assess risk of bias, confounding, and causality. The difference in proportion between cumulative one-year mortality and acute mortality was defined as post-acute mortality. Meta-analysis was done by sepsis definition categories with post-acute mortality as the primary outcome. Results The literature search identified 11,156 records, of which 59 studies met our inclusion criteria and 43 studies reported post-acute mortality. In patients who survived an index sepsis admission, the post-acute mortality was 16.1 % (95 % CI 14.1, 18.1 %) with significant heterogeneity (p |
| Databáze: | OpenAIRE |
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