Electromembrane extraction using deep eutectic solvents as the liquid membrane

Autor: Maria Muñoz, Frederik André Hansen, Elia Santigosa-Murillo, María Ramos-Payán, Elisabeth Leere Øiestad, Stig Pedersen-Bjergaard
Přispěvatelé: Universidad de Sevilla. Departamento de Química Analítica
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Hansen, F A, Santigosa-Murillo, E, Ramos-Payán, M, Muñoz, M, Leere Øiestad, E & Pedersen-Bjergaard, S 2021, ' Electromembrane extraction using deep eutectic solvents as the liquid membrane ', Analytica Chimica Acta, vol. 1143, pp. 109-116 . https://doi.org/10.1016/j.aca.2020.11.044
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
ISSN: 0003-2670
Popis: In this work, we investigated for the first time hydrophobic deep eutectic solvents (DES) as supported liquid membrane (SLM) for electromembrane extraction (EME). Camphor, coumarin, DL-menthol, and thymol were used as non-ionic DES components. Different DESs compositions were tested, to study systematically the importance of hydrogen bonding and dispersion/aromatic interactions during mass transfer across the SLM. Unexpectedly, mixtures of coumarin and thymol were highly efficient SLMs, and provided exhaustive or near-exhaustive extraction of non-polar bases, non-polar acids, and polar bases. SLMs with such performance for both bases and acids, in a large polarity window, are not found in current literature. The SLMs were highly aromatic, very strong hydrogen bonding donors, and moderately strong hydrogen bonding acceptors. Aromatic (π type) interactions were apparently very important for transfer of bases, while hydrogen bonding were dominant for acids. EME of six polar basic drugs from plasma, with a coumarin and thymol mixture as SLM, and combined with UHPLC-MS/MS analysis, was evaluated to test the potential for analytical applications. Plasma was diluted 1:1 with phosphate buffer pH 2.0. Calibration curves were linear in the therapeutic ranges (0.970 < R2 < 0.999), recoveries ranged between 47 and 93%, and repeatability was within 1.6–10.7% RSD. The clean-up efficiency was excellent and no matrix effects from plasma were seen. Presence of trace levels of coumarin in the acceptor phase was however found to cause some ion enhancement. Based on the current work, we foresee more research on the use of DES in EME. Agencia de Gestió d’Ajusts Universitaris i the Recerca 2017-SGR-32
Databáze: OpenAIRE
Externí odkaz: