Brain-derived neurotrophic factor (BDNF) gene not associated with antidepressant-induced mania

Autor:	Gwyneth Zai, Gregory W.H. Wong, James L. Kennedy, John Strauss, Emanuela Mundo
Rok vydání:	2007
Předmět:	medicine.medical_specialty Bipolar Disorder Genotype behavioral disciplines and activities chemistry.chemical_compound Gene Frequency Neurotrophic factors Internal medicine mental disorders medicine Humans Bipolar disorder Neurotransmitter Biological Psychiatry Alleles Brain-derived neurotrophic factor Depressive Disorder Polymorphism Genetic Brain-Derived Neurotrophic Factor medicine.disease Antidepressive Agents Genotype frequency Psychiatry and Mental health Endocrinology chemistry Case-Control Studies Synaptic plasticity Antidepressant medicine.symptom Psychology Neuroscience Mania
Zdroj:	Bipolar disorders. 9(5)
ISSN:	1398-5647
Popis:	Background: Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of bipolar disorder (BPD). Moreover, increasing BDNF production might be one of the mechanisms involved in the alleviation of depression and aggravation of mania in antidepressant treatment. Objectives: Thus, we hypothesized that a genetic variant within the BDNF gene might influence susceptibility to antidepressant-induced mania, as has been suggested previously. Methods: We performed a case–control study to test for allelic frequency and genotype distribution differences across six BDNF polymorphisms between 27 patients with antidepressant-induced mania (IM+) and 29 patients without antidepressant-induced mania (IM−). Results: We did not observe any significant difference in either allelic or genotype frequencies between the two groups. Conclusions: Our results did not support the BDNF link to mania hypothesis proposed previously. However, a larger sample would allow for greater power to determine smaller effects of the BDNF gene in antidepressant-induced mania.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10875df72e9972a46a9021bd662819a7 https://pubmed.ncbi.nlm.nih.gov/17680923 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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