Catecholamines and children obstructive sleep apnea: a systematic review
| Autor: | Franca Marino, Francesca De Bernardi, Marco Cosentino, Luana Nosetti, Eleonora Sica, Paolo Castelnuovo, Stefano Martini |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Sympathetic Nervous System Obstructive sleep apnea (OSA) Catecholamines Internal medicine medicine Humans In patient Child Sleep Apnea Obstructive business.industry General Medicine medicine.disease Sleep in non-human animals Pathophysiology respiratory tract diseases Obstructive sleep apnea medicine.anatomical_structure Breathing Research studies Cardiology Sympathetic nervous system (SNS) Sleep business Airway Catecholamines (CAs) |
| Zdroj: | Sleep Medicine. 87:227-232 |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2021.09.007 |
| Popis: | Introduction Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder in children and is characterized by recurrent total or partial upper airway collapse episodes during sleep. OSA is associated with cardiovascular, metabolic and neurobehavioural complications related to sympathetic nervous system (SNS) activation. A key role in originating these complications and in underlying pathophysiologic mechanisms can be attributed to altered catecholamines (CAs) metabolism. Methods A systematic review was performed according to the PRISMA Statement guidelines for research studies correlating OSA in children with catecholamines. Results Only 13 studies out of 151 reports were included in the review. Most studies (9 out of 13) showed increased secretion for some catecholamines in patients with a sleep-related breathing disorder or OSA compared to a control group or post treatment control group. Conclusion OSA can activate the sympathetic nervous system (SNS) and increase catecholamines (CAs) production, perhaps contributing to increased morbidity. However, underlying pathophysiologic mechanisms remain still unclear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect