Does focal inflammation have an impact on cognition in multiple sclerosis? An MRI study
| Autor: | Eleonora Cocco, M. Arru, Giuseppe Fenu, Maria Giovanna Marrosu, Lorena Lorefice, M.A. Barracciu, Marzia Fronza, Luciano Loi, Giancarlo Coghe, Jessica Frau |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Contrast Media Gadolinium Neuropsychological Tests Asymptomatic Gastroenterology 03 medical and health sciences Disability Evaluation 0302 clinical medicine Cognition Multiple Sclerosis Relapsing-Remitting Internal medicine medicine Humans 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Neuropsychological assessment Focal inflammation medicine.diagnostic_test business.industry Multiple sclerosis Neuropsychology Brain General Medicine medicine.disease Magnetic Resonance Imaging Linear Models Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Multiple sclerosis and related disorders. 23 |
| ISSN: | 2211-0356 |
| Popis: | Cognitive impairment concerns a significant percentage of patients with multiple sclerosis (MS). A transient impairment of cognition with a simultaneous presence of non-symptomatic gadolinium (Gd)-enhancing lesions in patients with MS was previously described. Our study aimed to evaluate modifications in cognitive function before and after the occurrence of asymptomatic MRI gadolinium (Gd)-enhancing lesions in relapsing MS patients.All patients underwent a neuropsychological evaluation before (30-60 days) and after (30-60 days) brain MRI with Gd administration. Patients were classified as Gd positive (presence of enhancing-lesions) and Gd negative (absence of enhancing-lesions). We also recruited a healthy controls group underwent to the same neuropsychological assessment for two times with the same timing of MS patients.We included 84 relapsing-remitting patients and 40 healthy controls. Brain MRI results showed that 14/84 (16.7%) patients had asymptomatic Gd-enhancing-lesion. No significant variation in cognitive performance between baseline and follow-up was observed in patients with or without MRI-enhancing lesions. However, an increase between baseline and follow-up was observed in the mean scores of the Symbol Digit Modality Test (41.9 at baseline versus 46.7 at follow-up, p : 0.001). This increase was significantly lower in Gd positive patients compared to Gd negative patients (mean increase 1.1 in Gd positive versus 4.9 in Gd negative, p: 0.001) and to healthy controls groups (mean increase 7.2; p 0.001) CONCLUSIONS: In our study, the absence of a practice effect in Gd positive compared to Gd negative patients and to healthy controls suggests a possible role of focal inflammation on cognitive function of MS patients. |
| Databáze: | OpenAIRE |
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