Atovaquone‐Proguanil versus Mefloquine for Malaria Prophylaxis in Nonimmune Travelers: Results from a Randomized, Double‐Blind Study
| Autor: | Neil S. Roskell, Hans Dieter Nothdurft, Dea Shaw, David Overbosch, J. Knobloch, Kevin C. Kain, Jeffrey D. Chulay, Ulrich Bienzle, Herbert J. Schilthuis, Paul D Clarke, Ron H Behrens, Stephen Toovey |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Proguanil Antimalarials Double-Blind Method Internal medicine parasitic diseases medicine Humans Child Atovaquone Aged Aged 80 and over Travel business.industry Mefloquine Malaria prophylaxis Middle Aged medicine.disease Atovaquone/proguanil Malaria Surgery Drug Combinations Treatment Outcome Infectious Diseases Tolerability Child Preschool Chemoprophylaxis Female business human activities Naphthoquinones medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 33:1015-1021 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/322694 |
| Popis: | Concerns about the tolerability of mefloquine highlight the need for new drugs to prevent malaria. Atovaquone-proguanil (Malarone; GlaxoSmithKline) was safe and effective for prevention of falciparum malaria in lifelong residents of malaria-endemic countries, but experience in nonimmune people is limited. In a randomized, double-blind study, nonimmune travelers received malaria prophylaxis with atovaquone-proguanil (493 subjects) or mefloquine (483 subjects). Information about adverse events (AEs) and potential episodes of malaria was obtained 7, 28, and 60 days after travel. AEs were reported by an equivalent proportion of subjects who had received atovaquone-proguanil or mefloquine (71.4% versus 67.3%; difference, 4.1%; 95% confidence interval, -1.71 to 9.9). Subjects who received atovaquone-proguanil had fewer treatment-related neuropsychiatric AEs (14% versus 29%; P=.001), fewer AEs of moderate or severe intensity (10% versus 19%; P=.001), and fewer AEs that caused prophylaxis to be discontinued (1.2% versus 5.0%; P=.001), compared with subjects who received melfoquine. No confirmed diagnoses of malaria occurred in either group. Atovaquone-proguanil was better tolerated than was mefloquine, and it was similarly effective for malaria prophylaxis in nonimmune travelers. |
| Databáze: | OpenAIRE |
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