No association between genetic variants in MAOA, OXTR, and AVPR1a and cooperative strategies

Autor: Mauricio Aspé-Sánchez, María I. Rivera-Hechem, Ricardo Andrés Guzmán, Carlos Rodríguez-Sickert, Víctor Landaeta-Torres, Gabriela M. Repetto, Tadeo Ramírez-Parada, Felipe Benavides
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Social Cognition
Male
Receptors
Vasopressin
Candidate gene
Heredity
genetic structures
Social Sciences
Genome-wide association study
Psychology
Cooperative Behavior
media_common
Multidisciplinary
Applied Mathematics
Genomics
Genetic Mapping
Receptors
Oxytocin
Physical Sciences
Medicine
Female
Research Article
Adult
Social Psychology
Adolescent
Genotype
media_common.quotation_subject
Science
Variant Genotypes
Biology
Game Theory
Genetics
Genome-Wide Association Studies
Humans
Association (psychology)
Monoamine Oxidase
Alleles
Sociality
Behavior
Polymorphism
Genetic
Cognitive Psychology
Biology and Life Sciences
Computational Biology
Human Genetics
Heritability
Genome Analysis
Human genetics
Altruistic Behavior
Prosocial Behavior
Games
Experimental
Genetic Loci
Evolutionary biology
Cognitive Science
Mathematics
Neuroscience
Diversity (politics)
Social behavior
Zdroj: PLoS ONE, Vol 15, Iss 12, p e0244189 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: The effort to understand the genetic basis of human sociality has been encouraged by the diversity and heritability of social traits like cooperation. This task has remained elusive largely because most studies of sociality and genetics use sample sizes that are often unable to detect the small effects that single genes may have on complex social behaviors. The lack of robust findings could also be a consequence of a poor characterization of social phenotypes. Here, we explore the latter possibility by testing whether refining measures of cooperative phenotypes can increase the replication of previously reported associations between genetic variants and cooperation in small samples. Unlike most previous studies of sociality and genetics, we characterize cooperative phenotypes based on strategies rather than actions. Measuring strategies help differentiate between similar actions with different underlaying social motivations while controlling for expectations and learning. In an admixed Latino sample (n = 188), we tested whether cooperative strategies were associated with three genetic variants thought to influence sociality in humans—MAOA-uVNTR, OXTR rs53576, and AVPR1 RS3. We found no association between cooperative strategies and any of the candidate genetic variants. Since we were unable to replicate previous observations our results suggest that refining measurements of cooperative phenotypes as strategies is not enough to overcome the inherent statistical power problem of candidate gene studies.
Databáze: OpenAIRE
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