Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons

Autor: Miriam Melis, Bastien Redon, François Georges, Maria-Carmen Medrano, Emma Mesguich, Francis Chaouloff, Christopher Stevens, Imane Hurel, Giovanni Marsicano
Přispěvatelé: NeuroCentre Magendie, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Universita degli Studi di Cagliari [Cagliari], Georges, Francois, Università degli Studi di Cagliari = University of Cagliari (UniCa), IMN (UMR 5293)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Medicine (miscellaneous)
Craving
wheel-running
Mice
0302 clinical medicine
Cocaine
Dopamine Uptake Inhibitors
Dronabinol
exercise
musculoskeletal
neural
and ocular physiology
Dopaminergic
drug
Ventral tegmental area
Psychiatry and Mental health
medicine.anatomical_structure
Excitatory postsynaptic potential
medicine.symptom
Cues
Reinforcement
Psychology
psychological phenomena and processes
medicine.drug
Neurocentre Magendie
Endocannabinoids & NeuroAdaptation Keywords: exercise motivation
AMPA receptor
AMPAR/NMDAR ratio
Receptors
N-Methyl-D-Aspartate
03 medical and health sciences
Reward
motivation
Dopamine
mental disorders
medicine
Animals
VTA dopaminergic neurones
Receptors
AMPA
Amphetamine
Pharmacology
business.industry
Dopaminergic Neurons
Ventral Tegmental Area
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Excitatory Postsynaptic Potentials
reinstatement
030227 psychiatry
Mice
Inbred C57BL
nervous system
Synaptic plasticity
Synapses
business
Neuroscience
030217 neurology & neurosurgery
Zdroj: Addiction Biology
Addiction Biology, Wiley, In press, ⟨10.1111/adb.12967⟩
Addiction Biology, In press, ⟨10.1111/adb.12967⟩
Addiction Biology, Wiley, 2020, ⟨10.1111/adb.12967⟩
ISSN: 1355-6215
1369-1600
DOI: 10.1111/adb.12967⟩
Popis: International audience; Physical exercise, which can be addictogenic on its own, is considered a therapeutic alternative for drug craving. Exercise might thus share with drugs the ability to strengthen excitatory synapses onto ventral tegmental area (VTA) dopaminergic neurones, as assessed by the ratio of AMPA receptor (AMPAR)‐mediated excitatory postsynaptic currents (EPSCs) to NMDA receptor (NMDAR)‐mediated EPSCs. As did acute cocaine, amphetamine, or Δ9‐tetrahydrocannabinol (THC) pretreatments, an acute 1‐h wheel‐running session increased the AMPAR/NMDAR ratio in VTA dopaminergic neurones. To dissect the respective influences of wheel‐running seeking and performance, mice went through an operant protocol wherein wheel‐running was conditioned by nose poking under fixed ratio schedules of reinforcement. Conditioned wheel‐running increased the AMPAR/NMDAR ratio to a higher extent than free wheel‐running, doing so although running performance was lower in the former paradigm than in the latter. Thus, the cue‐reward association, rather than reward consumption, played a major role in this increase. The AMPAR/NMDAR ratio returned to baseline levels in mice that had extinguished the cued‐running motivated task, but it increased after a cue‐induced reinstatement session. The amplitude of this increase correlated with the intensity of exercise craving, as assessed by individual nose poke scores. Finally, cue‐induced reinstatement of running seeking proved insensitive to acute cocaine or THC pretreatments. Our study reveals for the first time that the drive for exercise bears synaptic influences on VTA dopaminergic neurones which are reminiscent of drug actions. Whether these influences play a role in the therapeutic effects of exercise in human drug craving remains to be established.
Databáze: OpenAIRE
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