Effects of Synthetic Single-and Multistranded Polynucleotides on Human Monocyte IgG Receptor Activity In Vitro
| Autor: | Manfred E. Schmidt, Steven D. Douglas |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Receptors
Drug Biology Monocytes General Biochemistry Genetics and Molecular Biology Structure-Activity Relationship medicine Humans Receptor Incubation Monocyte Cell Membrane medicine.disease Molecular biology In vitro Leukemia Poly C Poly I-C medicine.anatomical_structure Biochemistry Poly I Polynucleotide Immunoglobulin G biology.protein Nucleic Acid Conformation Antibody IgG receptor activity Polyribonucleotides |
| Zdroj: | Experimental Biology and Medicine. 151:376-379 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-151-39214 |
| Popis: | SummaryHuman peripheral monocytes demonstrated a higher IgG receptor activity in vitro after incubation with multistranded polynucleotides (poly(I:C) and poly(I:C:U)) after 6-hr cultivation periods. These changes were most pronounced using SRBC coated with low anti-Forssman antibody concentrations (EA, 1:1600 and 1:6400). Polyinosinic and polycytidylic acids failed to show changes in receptor activity. These findings suggest monocyte activation in vitro by multistranded polynucleotides and may in part explain their antitumor activity.This research was supported in part by the National Insititutes of Health USPHS Grant No. AI-12478-02 and the National Leukemia Association, Inc., and in part by Deutsche Forschungsgemeinschaft. |
| Databáze: | OpenAIRE |
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