Paradoxical association between lipoprotein cholesterol levels and left atrial function in hypertensive diabetic patients: A speckle tracking study
Autor: | Tuncay Kırış, Ali Gökhan Özyıldız, Mustafa Çetin, Ezgi Kalaycıoğlu |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Statin medicine.drug_class Lipoproteins Speckle tracking echocardiography 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Radiology Nuclear Medicine and imaging Heart Atria Risk factor Ejection fraction business.industry Atrial fibrillation medicine.disease Cholesterol medicine.anatomical_structure Ventricle Hypertension Cardiology Atrial Function Left business Body mass index |
Zdroj: | Journal of Clinical Ultrasound. 49:667-673 |
ISSN: | 1097-0096 0091-2751 |
Popis: | BACKGROUND Studies have shown that subclinical left atrial (LA) dysfunction can be diagnosed with two-dimensional speckle tracking echocardiography (2D-STE). Although low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular diseases, recent studies have reported a paradoxical relationship between LDL-C level and atrial fibrillation. In this study, we investigated the relationship between LDL-C levels and LA function. METHODS In 168 patients with the diagnosis of hypertension and diabetes, transthoracic echocardiography with LA 2D-STE was performed. The patients were then divided into two groups: normal LA-strain (n = 94) or impaired LA-strain (n = 74). The relationship between LDL-C and LA function was analyzed. RESULTS Patients with impaired LA-strain had higher body mass index (BMI) (p = 0.029), higher statin usage (p = 0.003), and lower LDL-C levels (p = 0.001) than patients with normal LA-strain. They also had lower left ventricle ejection fraction (LVEF) (p = 0.047) and higher E-wave velocity (mitral e, m/s) (p = 0.020). Multivariate logistic regression analysis showed that lower LDL-C (p = 0.034), higher BMI (p = 0.004), lower LVEF (p = 0.004), and higher E-wave velocity (p = 0.003) values were independently associated with impaired LA-strain. The area under the receiver operating curve of LDL-C in predicting impaired LA-strain was 0.645 (0.564-0.730, p |
Databáze: | OpenAIRE |
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