Antioxidant and Antimicrobial Activities of Naturally Occurring Flavonoids from M. heterophylla and the Safety Evaluation in Wistar Rats
| Autor: | Abdulsalam Hassan Adewuyi, Shukurat Bisola Babalola, Bala Alkali Mohammed, Stephen Damaola Ariyeloye, Bashir Lawal, Sheriff Itopa Umar, Cyril Ifeanyi Obiekezie |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Iranian Journal of Toxicology, Vol 13, Iss 4, Pp 39-44 (2019) |
| ISSN: | 2251-9459 2008-2967 |
| Popis: | Background: Maytenus heterophylla (M. heterophylla) is commonly used in African traditional medicine for the management of various ailments. The present study evaluated the antioxidant, antimicrobial and safety properties of the Flavonoid extract of M. heterophylla in Wister rats. Methods: The Flavonoid was subjected to antibacterial study via agar well diffusion method, and antioxidant study using 2, 2′-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant properties (FRAP) assays. Subacute toxicity were carried out by the oral administration of the extract at a daily dose of 50 or 100mg/kg for 28 days. Results: The extract produced significant antioxidants activities with IC50 of 33.07±0.84 µg/mL & 38.08±0.89 μg/mL in DPPH and FRAPS models respectively. It produced a dose-dependent inhibition of S. aureus, E.coli, P. aeruginosa, K. pneumonia and S. Typhi with MIC between 12.5µg/mL to 25µg/mL. The flavonoid was safe on acute exposure to rats (LD50> 5000 mg/kg). However, the chronic exposure significantly (p |
| Databáze: | OpenAIRE |
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