Elevated neutrophil-to-lymphocyte ratio is an independent poor prognostic factor in patients with intrahepatic cholangiocarcinoma
| Autor: | Guohe Lin, Jun Wang, Zeyu Shuang, S. W. Li, Yize Mao, Jianlin Chen, Yongcheng Liu, Shengping Li |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Pathology Neutrophils medicine.medical_treatment Kaplan-Meier Estimate CD8+ T cells Gastroenterology Disease-Free Survival Cholangiocarcinoma 03 medical and health sciences 0302 clinical medicine Surgical oncology intrahepatic cholangiocarcinoma neutrophil-to-lymphocyte ratio Internal medicine medicine Cytotoxic T cell Humans Lymphocyte Count Lymphocytes Neutrophil to lymphocyte ratio Intrahepatic Cholangiocarcinoma Aged Proportional Hazards Models Retrospective Studies Proportional hazards model business.industry fungi Cancer Middle Aged medicine.disease Prognosis CD4+ T cells 030104 developmental biology Oncology Bile Duct Neoplasms 030220 oncology & carcinogenesis Female Hepatectomy business CD8 Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Guohe Lin 1,2,* , Yongcheng Liu 1,4,* , Shuhong Li 1,2,5,* , Yize Mao 1,2,3 , Jun Wang 1,2,3 , Zeyu Shuang 1,2,3 , Jianlin Chen 1,2,3 and Shengping Li 1,2,3 1 State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China 2 National Collaborative Innovation Center for Cancer Medicine, Guangzhou, China 3 Department of Hepatobiliary Oncology, Sun-Yat-sen University Cancer Center, Guangzhou, China 4 Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China 5 Department of Endoscopy, Sun Yat-sen University Cancer Center, Guangzhou, China * These authors have contributed equally to this work Correspondence to: Shengping Li, email: // Keywords : intrahepatic cholangiocarcinoma, neutrophil-to-lymphocyte ratio, CD4+ T cells, CD8+ T cells, prognosis Received : July 23, 2015 Accepted : February 13, 2016 Published : February 24, 2016 Abstract We investigated whether elevated neutrophil-to-lymphocyte ratio ( NLR ) was associated with poor anti-tumor immunity and prognosis in patients with intrahepatic cholangiocarcinoma ( ICC ). Clinicopathologic data of 102 patients with ICC who underwent hepatectomy was retrospectively analyzed. The Kaplan-Meier method and Cox regression model were used to analyze the survival and prognosis. The percentage of overall lymphocytes , T cells and CD8+ T cells in the high NLR group was lower than that in the low NLR group. The percentage of PD-1+CD4+ and PD-1+CD8+ T cells was higher and the percentage of IFN-γ+CD4+ and IFN-γ+CD8+ T cells was lower in the high NLR group than that in the low NLR group ( p = 0.045, p = 0.008; p = 0.012, p = 0.006 ). Density of tumor-infiltrating CD3+ T cells in the high NLR group was lower than that in the low NLR group ( p < 0.001 ). Elevated NLR was an independent predictor for poor overall survival ( OS; p = 0.035 ) and recurrence-free survival ( RFS; p = 0.008 ). These results indicate that elevated NLR is associated with poor anti-tumor immunity and could be a poor biomarker for prognosis in patients with ICC. |
| Databáze: | OpenAIRE |
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