The distensibility of the resistance vessels of skeletal muscle in hypertensive patients

Autor: Poul Ebbe Nielsen, Hartling Oj, Svendsen Tl, Jens Trap-Jensen
Rok vydání: 1978
Předmět:
Zdroj: Acta Physiologica Scandinavica. 103:430-436
ISSN: 1365-201X
0001-6772
DOI: 10.1111/j.1748-1716.1978.tb06237.x
Popis: The distensibility of the resistance vessels of skeletal muscle was evaluated in 23 patients with essential arterial hypertension (WSHO grade I--II), and in 14 normotensive control sugjects. Five of the hypertensive patients were well treated for over 2 years and 18 were untreated. The 133Xenon wash-out rate from the anterior tibial muscle during reactive hyperemia was recorded before and during an increase of the vascular transmural pressure, brought about by application of a subatmospheric pressure to the leg. At ambient pressure the 133Xenon wash-out rate did not differ between the normotensive and hypertensive subjects, reflecting equal muscle blood flows. However, when the transmural pressure was augmented the 133Xenon wash-out rate in the normotensive subjects increased about twice as much as in the hypertensive patients. This suggests a decreased distensibility of the resistance vessels in hypertensive patients as compared to normotensive subjects, and supports the concept that structural changes of these vessels take place in arterial hypertension. Since the vascular distensibility was equally reduced in the untreated and well treated hypertensive patients it is indicated that the structural changes in the resistance vessels of the leg muscles do not readily decline during antihypertensive treatment.
Databáze: OpenAIRE
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