Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization
| Autor: | Phillip D. Markham, Pranab K. Chanda, Robert J. Natuk, Maria Myagkikh, Mark R. Wade, Narender K. Kalyan, Alan R. Davis, Susan Zolla-Pazner, Shabnam Alipanah, Shri C.S. Murthy, Larry O. Arthur, Robert C. Gallo, Kathy Steimer, Marjorie Robert-Guroff, Satoshi Mizutani, Marvin S. Reitz, Faruk Sinangil, Stephen M. Nigida, Michael D. Lubeck, Jorg Eichberg, Kristine Aldrich, Paul P. Hung |
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| Rok vydání: | 1997 |
| Předmět: |
Pan troglodytes
Recombinant Fusion Proteins viruses Human immunodeficiency virus (HIV) Priming (immunology) HIV Infections HIV Envelope Protein gp120 medicine.disease_cause General Biochemistry Genetics and Molecular Biology Adenoviridae HIV Envelope Protein gp160 Acquired immunodeficiency syndrome (AIDS) medicine Animals Cytotoxic T cell Neutralizing antibody Vaccines biology Vaccination virus diseases General Medicine medicine.disease Virology Immunology HIV-1 biology.protein Female Antibody T-Lymphocytes Cytotoxic |
| Zdroj: | Nature Medicine. 3:651-658 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/nm0697-651 |
| Popis: | A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to low-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans. |
| Databáze: | OpenAIRE |
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