Do catecholamines influence the level of plasma leptin in patients with phaeochromocytoma?
Autor: | Włodzimierz Januszewic, Hanna Ignatowska-Świtalska, Krystyna Kuczyńska, Witold Cieśla, Hanna Berent, Bożenna Wocial, Małgorzata Dutkiewicz-Raczkowska, Mieczysław Szostek, Tadeusz Feltynowski, Jolanta Chodakowska |
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Rok vydání: | 2002 |
Předmět: |
Microbiology (medical)
Adult Leptin Male medicine.medical_specialty Epinephrine Clinical Biochemistry Immunology Adrenal Gland Neoplasms Pheochromocytoma Microbiology High-performance liquid chromatography Basal (phylogenetics) Norepinephrine Internal medicine medicine Immunology and Allergy Humans In patient Chemistry digestive oral and skin physiology Biochemistry (medical) Radioimmunoassay Sympathetic activity Middle Aged medicine.disease Neoplasm Proteins Infectious Diseases Endocrinology Catecholamine Female hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | British journal of biomedical science. 59(3) |
ISSN: | 0967-4845 |
Popis: | The relationship between plasma leptin and catecholamine concentrations during chronic and acute catecholamine excess is studied. Patients with phaeochromocytoma, divided according to gender, were examined under basal conditions (n = 18) and at selected time-points during surgical removal of the tumour (n = 12). Appropriate controls were used (n = 23) for the basal study. Plasma leptin was determined by radioimmunoassay (RIA) and plasma noradrenaline (NA) and adrenaline (A) by high-performance liquid chromatography (HPLC). Statistical evaluation employed Student's t-test, Wicoxon test and Spearman's correlation coefficient. Gender-related differences in plasma leptin in normal subjects was confirmed, and these were maintained in the patients. Phaeochromocytoma patients had normal plasma leptin levels in the basal state and decreased levels following the massive catecholamine surge provoked by surgery. Plasma leptin concentration did not correlate with plasma NA or A in either group studied. In the patients with phaeochromocytoma, acute but not chronic catecholamine excess affected plasma leptin, suggesting a role for sympathetic activity in modulating leptin release. |
Databáze: | OpenAIRE |
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