IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory
| Autor: | M Scibiorek, S Pillay, B O Moses, Inssaf Berkiks, Frank Brombacher, Tiroyaone M Brombacher |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Molecular biology Immunology lcsh:Medicine Alpha (ethology) Morris water navigation task Receptors Cell Surface Tropomyosin receptor kinase B Hippocampal formation Biology Hippocampus Article Behavioural methods Immunological techniques Mice Cognition Memory Animals Psychology Maze Learning lcsh:Science Receptor Mice Inbred BALB C Interleukin-13 Multidisciplinary Brain-Derived Neurotrophic Factor lcsh:R lcsh:Q Interleukin-4 Signal transduction Neuroscience Alpha chain Signal Transduction |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-73574-3 |
| Popis: | Like pro-inflammatory cytokines, the role of anti-inflammatory cytokines in both learning and memory has been investigated, revealing beneficial effects for both interleukin-4 and interleukin-13 via the common interleukin-4 receptor alpha chain complex. In this study, using the Morris water maze spatial task for cognition, we compared interleukin-4 receptor alpha- deficient mice and their ligands interleukin-4/ interleukin-13 double deficient mice, on a Balb/c background. We demonstrate that while interleukin-4/ interleukin-13 double deficient mice are significantly impaired in both learning and reference memory, interleukin-4 receptor alpha-deficiency impairs only reference memory, compared to the wild-type control mice. In order to better understand how interleukin-4 receptor alpha- deficient mice are able to learn but not remember, we investigated the BDNF/TrkB- and the ARC-signaling pathways. We show that interleukin-4 receptor alpha-deficiency disrupts activation of BDNF/TrkB- and ARC-signaling pathways during reference memory, while the pathway for spatial learning is spared. |
| Databáze: | OpenAIRE |
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