Synthesis of quaternary centres by single electron reduction and alkylation of alkylsulfones

Autor:	Yasuyo Tahara, Daisuke Yokogawa, Jacky C.-H. Yim, Cathleen M. Crudden, Masakazu Nambo
Rok vydání:	2021
Předmět:	Generation process 010405 organic chemistry Radical General Chemistry Alkylation 010402 general chemistry 01 natural sciences 0104 chemical sciences Chemistry chemistry.chemical_compound Single electron chemistry Computational chemistry Intramolecular force Functional group Reduction (mathematics)
Zdroj:	Chemical Science
ISSN:	2041-6539 2041-6520
DOI:	10.1039/d1sc00133g
Popis:	A new method for the generation of tertiary radicals through single electron reduction of alkylsulfones promoted by Zn and 1,10-phenanthroline has been developed. These radicals could be employed in the Giese reaction, affording structurally diverse quaternary products in good yields. With the high modularity and functional group compatibility of sulfones, the utility of this method was demonstrated by intramolecular and iterative reactions to give complex structures. The radical generation process was investigated by control experiments and theoretical calculations. A new method for the generation of tertiary radicals through single electron reduction of alkylsulfones promoted by Zn and 1,10-phenanthroline has been developed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1076e927d0189092309eef42bfe22e28 https://doi.org/10.1039/d1sc00133g Zobrazit plný text záznamu