Configurational analysis of long-chain alkanediols
| Autor: | Patricia C. Bandi, Harald H.O. Schmid |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Stereochemistry
Molecular Conformation Stereoisomerism Biochemistry chemistry.chemical_compound Structure-Activity Relationship Choline Structure–activity relationship Animals Molecular Biology Myelin Sheath Phosphocholine Skin Wax Organic Chemistry Fatty Acids Brain Cell Biology Rat brain Rats chemistry visual_art visual_art.visual_art_medium Phosphatidylcholines Chromatography Thin Layer Enantiomer Fatty Alcohols Hydroxy Acids Long chain |
| Zdroj: | Chemistry and physics of lipids. 17(2-3 SPEC) |
| ISSN: | 0009-3084 |
| Popis: | Long-chain 1,2-alkanediols can be separated into their enantiomers by thin-layer chromatography of the bis-L-acetylmandelates. The method is also applicable to the separation of enantiomeric 1,3-alkanediols. Both 2-hydroxy fatty acids and 1,2-alkanediols derived from diester waxes of rat skin have the D-configuration. The D-enantiomer of 2DL-1,2-octadecanediol is preferentially utilized by myelinating rat brain in the formation of choline phospholipids having a 1,2-octadecanediol backbone. The D-configuration of the chiral center at carbon-2 of 2-acyl-1,2-alkanediol phosphocholine corresponds to the configuration at carbon-2 of 1,2-diacyl-sn-glycero-3-phosphocholine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|