Plasma tyrosine/neutral amino acid ratio correlated with clinical response to nortriptyline in endogenously depressed patients
| Autor: | K. Ødum, L. Kirk, F. Fog-Møller, M. Bjerre, S.E. Møller, A. Knudsen |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Biological Availability Endogeny Nortriptyline Therapeutic index Internal medicine medicine Humans Amino Acids Tyrosine Psychiatric Status Rating Scales chemistry.chemical_classification Depressive Disorder Tryptophan Middle Aged Rating score Amino acid Psychiatry and Mental health Clinical Psychology Endocrinology chemistry Antidepressant Female medicine.drug |
| Zdroj: | Journal of Affective Disorders. 9:223-229 |
| ISSN: | 0165-0327 |
| Popis: | Ratios in plasma of tryptophan (Trp) and tyrosine (Tyr) to other large neutral amino acids were determined in 26 endogenous depressives before and after treatment with nortriptyline in doses adequate to achieve a steady-state serum level between 70 and 130 ng/ml, i.e., within the recommended therapeutic range. Pretreatment plasma Trp ratio and Tyr ratio were normal and did not change significantly during treatment. The plasma Trp and Tyr concentrations and the plasma Trp ratio showed no significant association with the therapeutic response. However, the pretreatment plasma Tyr ratio correlated significantly and directly with the final Hamilton rating score, and inversely with the per cent reduction of Hamilton rating score. Moreover, depressives with plasma Tyr ratio below the normal mean showed significantly greater clinical improvement than patients with higher plasma Tyr ratio with comparable serum nortriptyline levels. Evidence has been presented that biochemical variables in depressed patients are important determinants of clinical improvement following pharmacotherapeutic treatment. Moreover, the results suggest that the plasma Tyr ratio may be a guideline for antidepressant response to nortriptyline. |
| Databáze: | OpenAIRE |
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