Nitrogen sparing induced early in starvation by infusion of branched-chain ketoacids
| Autor: | Mackenzie Walser, Daniel G. Sapir |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
medicine.medical_specialty Nitrogen Endocrinology Diabetes and Metabolism Glucagon Endocrinology Alloisoleucine Valine Internal medicine medicine Humans Urea Obesity Amino Acids chemistry.chemical_classification Fasting Keto Acids Amino acid Uric Acid Glutamine Quaternary Ammonium Compounds chemistry Starvation Creatinine Ketone bodies Female Leucine Isoleucine |
| Zdroj: | Metabolism: clinical and experimental. 26(3) |
| ISSN: | 0026-0495 |
| Popis: | The α-ketoanalogues of the branched-chain amino acids were administered to fasting subjects to determine whether or not they promoted nitrogen sparing. Two fasting studies were carried out in each subject. During the first week of one of the two fasts 4.7 g of a mixture of the α-ketoanalogues of valine, leucine, and isoleucine were infused daily. No infusions were administered during the other fast, which served as a control. Urinary urea and calculated total urinary nitrogen were significantly lower during both the week of infusions and the ensuing week of fasting after the infusions were discontinued. Immediately after ketoacid infusions, plasma branched-chain amino acids, including alloisoleucine, rose, while alanine and several other amino acids (but not glutamine) fell. There were no differences between the two fasts with respect to ketone bodies, free fatty acids, glucose, insulin, or glucagon concentrations. We conclude that branched-chain ketoacids spare nitrogen early in fasting and that this effect persists after they are metabolized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|