The increase of osteopontin and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen enhances the risk of hip fracture in the elderly

Autor: Xie Liangwen, He‐Guo Cai, Lin Jianchun, Rui‐Ren Liu, Liu Zhongguo, Huang‐Lin Xie
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
osteopontin
Clinical Biochemistry
Logistic regression
Body Mass Index
0302 clinical medicine
Bone Density
Immunology and Allergy
Osteopontin
Research Articles
Bone mineral
Aged
80 and over
Hip fracture
biology
Mortality rate
Hematology
Middle Aged
Predictive value
Medical Laboratory Technology
Milk
β‐carboxy‐terminal cross‐linking telopeptide of type I collagen
030220 oncology & carcinogenesis
Female
Type I collagen
Research Article
Microbiology (medical)
musculoskeletal diseases
medicine.medical_specialty
Frail Elderly
Collagen Type I
03 medical and health sciences
Age Distribution
N-terminal telopeptide
stomatognathic system
Internal medicine
medicine
Animals
Humans
Aged
business.industry
Hip Fractures
Biochemistry (medical)
Public Health
Environmental and Occupational Health
medicine.disease
030104 developmental biology
Case-Control Studies
hip fracture in the elderly
biology.protein
Osteoporosis
business
bone mineral density
Peptides
Biomarkers
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background Hip fracture in the elderly is a health burden worldwide due to its high mortality rate. This study was conducted to determine the possible mechanisms of osteopontin (OPN) and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen (β‐CTX) in hip fracture in the elderly. Materials and Methods In the study, we recruited 108 elderly patients with hip fracture diagnosed from May 2012 to May 2015 at the Third Hospital of Xiamen and 86 healthy individuals without a history of hip fracture were taken as controls. Serum levels of OPN and β‐CTX were then determined. The T and Z values for bone mineral density (BMD) were also measured. Moreover, logistic regression analysis was performed to assess the risk and protective factors for hip fracture in the elderly. Results Serum levels of both OPN and β‐CTX were increased in elderly patients with hip fracture. OPN was positively correlated with β‐CTX. In addition, the levels of OPN and β‐CTX shared a positive association with the age, and a negative association with the BMD, in terms of T and Z values of the hip. In addition, increased BMD and outdoor sports might be protective factors for hip fracture, and an increase in levels of OPN and β‐CTX might be associated with a higher risk of hip fracture in the elderly population. Discussion Collectively, increased serum levels of OPN and β‐CTX might be correlated with a higher risk of a hip fracture and have predictive values in the occurrence of hip fracture in the elderly.
Databáze: OpenAIRE
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