Preterm Birth as a Risk Factor for Metabolic Syndrome and Cardiovascular Disease in Adult Life: A Systematic Review and Meta-Analysis
| Autor: | Antonis Analytis, Tania Siahanidou, Emmanouil Zoumakis, Panagiota Markopoulou, Eleni Papanikolaou |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Metabolic Syndrome medicine.medical_specialty business.industry Disease medicine.disease Fat mass 03 medical and health sciences Adult life 0302 clinical medicine Insulin resistance Cardiovascular Diseases Risk Factors 030225 pediatrics Internal medicine Meta-analysis Pediatrics Perinatology and Child Health medicine Humans Premature Birth 030212 general & internal medicine Risk factor Metabolic syndrome business Cardiovascular outcomes |
| Zdroj: | The Journal of pediatrics. 210 |
| ISSN: | 1097-6833 |
| Popis: | To determine if preterm birth is associated with components of the metabolic syndrome in adult life.A structured literature search was performed using PubMed. All comparative studies reported metabolic and cardiovascular outcomes in adults (≥18 years of age) born preterm (37 weeks of gestation) compared with adults born at term (37-42 weeks of gestation) and published through March 2018 were included. The major outcomes assessed were body mass index, waist circumference, waist-to-hip ratio, fat mass, systolic blood pressure (SBP), diastolic blood pressure (DBP), 24-hour SBP, 24-hour DBP, endothelium-dependent brachial artery flow-mediated dilation, carotid intima-media thickness, pulse wave velocity, fasting glucose and insulin, Homeostasis Model Assessment-Estimated Insulin Resistance Index, and lipid profiles. Quality appraisal was performed using a modified version of the Newcastle-Ottawa scale. A meta-analysis was performed for comparable studies which reported sufficient data.Forty-three studies were included, including a combined total of 18 295 preterm and 294 063 term-born adults. Prematurity was associated with significantly higher fat mass (P = .03), SBP (P .0001), DBP (P .0001), 24-hour SBP (P .001), and 24-hour DBP (P .001). Furthermore, preterm-born adults presented higher values of fasting glucose (P = .01), insulin (P = .002), Homeostasis Model Assessment-Estimated Insulin Resistance Index (P = .05), and total cholesterol levels (P = .05) in comparison with adults born at term, in random effect models. No statistically significant difference was found between preterm and term-born adults for the other outcomes studied.Preterm birth is strongly associated with a number of components of the metabolic syndrome and cardiovascular disease in adult life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect