Platelet Aggregation and Release of Atp in Patients with Hepatic Cirrhosis
| Autor: | E Fischer, S Ingeberg, P Jacobsen, K D Bentsen |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Alcoholic liver disease Cirrhosis Platelet Aggregation Platelet Function Tests medicine.diagnostic_test Liver Cirrhosis Biliary business.industry Gastroenterology medicine.disease Adenosine In vitro Liver disease Adenosine Triphosphate Primary biliary cirrhosis Liver Function Tests Liver Cirrhosis Alcoholic Internal medicine medicine Humans Platelet Liver function tests business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 20:285-288 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365528509091651 |
| Popis: | The purpose of this study was to assess the platelet aggregation and releasable platelet ATP in patients with alcoholic cirrhosis (n = 10) and primary biliary cirrhosis (n = 10). In patients with liver disease a significant decrease was found in both adenosine diphosphate-induced aggregation (P less than 0.01) and collagen-induced aggregation (P less than 0.001) compared with that of controls, but there was no significant difference between the two groups of patients. Patients with primary biliary cirrhosis release smaller amounts of ATP than patients with alcoholic cirrhosis, and compared with the controls there was a significant (P less than 0.001) decrease in the releasable ATP in the patient groups. These results suggest that platelets are damaged during an intravascular activation (loss of granules), which gives rise to their subsequent hypo-function when tested in vitro. |
| Databáze: | OpenAIRE |
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