Differences between predictive factors for early neurological deterioration due to hemorrhagic and ischemic insults following intravenous recombinant tissue plasminogen activator
| Autor: | Kei Ichiro Takase, Taketo Hatano, Takeshi Yamada, Konosuke Furuta, Ryo Yamasaki, Jun Ichi Kira, Koji Tanaka, Shoji Matsumoto, Sukehisa Nagano |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Article Recurrence Internal medicine Medicine Humans Symptomatic intracranial hemorrhage Risk factor Stroke Aged Retrospective Studies Aged 80 and over Hematology Ischemic stroke medicine.diagnostic_test business.industry Ischemic Change Magnetic resonance imaging Odds ratio Thrombolysis Middle Aged medicine.disease Confidence interval Tissue Plasminogen Activator Cardiology Female Early neurological deterioration Nervous System Diseases Cardiology and Cardiovascular Medicine business Intracranial Hemorrhages |
| Zdroj: | Journal of Thrombosis and Thrombolysis |
| ISSN: | 1573-742X |
| Popis: | Early neurological deterioration (END) following intravenous recombinant tissue plasminogen activator (rt-PA) treatment is a serious clinical event that can be caused by hemorrhagic or ischemic insult. We investigated the differences in predictive factors for END due to hemorrhagic and END due to ischemic insults. Consecutive patients from four hospitals who received 0.6 mg/kg intravenous rt-PA for acute ischemic stroke were retrospectively recruited. END was defined as a National Institutes of Health Stroke Scale (NIHSS) score ≥ 4 points within 24 h compared with baseline. END was classified into those due to hemorrhagic (ENDh) or ischemic (ENDi) insult based on computed tomography (CT) or magnetic resonance imaging. Risk factors associated with ENDh and ENDi were investigated by comparison with non-END cases. A total of 744 patients (452 men, median 75 years old) were included. END was observed in 79 patients (10.6%), including 22 ENDh (3.0%) and 57 ENDi (7.7%), which occurred within a median of 7 h after treatment. Multivariate analyses showed that higher pretreatment NIHSS score (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.00–1.13) and pretreatment with antiplatelets (OR 2.84, 95% CI 1.08–7.72) were associated with ENDh. Extensive early ischemic change (Alberta Stroke Program Early CT Score ≤ 7 on CT or ≤ 6 on diffusion-weighted imaging; OR 2.80, 95% CI 1.36–5.64) and large artery occlusions (OR 3.09, 95% CI 1.53–6.57) were associated with ENDi. Distinct factors were predictive for the END subtypes. These findings could help develop preventative measures for END in patients with the identified risk factors. |
| Databáze: | OpenAIRE |
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