Lithothamnion muelleri treatment ameliorates inflammatory and hypernociceptive responses in antigen-induced arthritis in mice
| Autor: | Fernando Lopes, Mauro M. Teixeira, Caio T. Fagundes, Bruna G. Malagoli, Daniela Sachs, Danielle G. Souza, José Hugo de Sousa Gomes, Fernão Castro Braga, Fernanda M. Coelho, Vivian Vasconcelos Costa, Tarcília Aparecida Silva, Vanessa Pinho, Kátia D. Silveira, Lívia D. Tavares, Celso Martins Queiroz-Junior, Flávio A. Amaral |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Nociception Chemokine Anti-Inflammatory Agents Arthritis lcsh:Medicine Inflammation Calcium Carbonate Polysaccharides Cell Adhesion Leukocytes medicine Animals lcsh:Science Analgesics Multidisciplinary biology business.industry Synovial Membrane lcsh:R Endothelial Cells Flow Cytometry medicine.disease Arthritis Experimental Mice Inbred C57BL CXCL1 CXCL2 medicine.anatomical_structure Rheumatoid arthritis Rhodophyta Immunology biology.protein Experimental pathology Joints lcsh:Q Lymph Nodes Synovial membrane medicine.symptom business Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 3, p e0118356 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Rheumatoid Arthritis (RA) is a chronic disease characterized by persistent inflammation and pain. Alternative therapies to reduce these symptoms are needed. Marine algae are valuable sources of diverse bioactive compounds. Lithothamnion muelleri (Hapalidiaceae) is a marine algae with anti-inflammatory, antitumor, and immunomodulatory properties. Here, we investigated the potential anti-inflammatory and analgesic activities of L. muelleri in a murine model of antigen-induced arthritis (AIA) in mice. Our results demonstrate that treatment with L. muelleri prevented inflammation and hypernociception in arthritic mice. Mechanistically, the crude extract and the polysaccharide-rich fractions of L. muelleri may act impairing the production of the chemokines CXCL1 and CXCL2, and consequently inhibit neutrophil influx to the knee joint by dampening the adhesion step of leukocyte recruitment in the knee microvessels. Altogether our results suggest that treatment with L.muelleri has a potential therapeutic application in arthritis treatment. |
| Databáze: | OpenAIRE |
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