Association of hypoxia inducible factor-1α polymorphisms with susceptibility to non–small-cell lung cancer
Autor: | Shuo-Chueh Chen, Wei-Erh Cheng, Yao-Ling Lee, Wei Chen, Chiao-Wen Lin, Wu-Hsien Kuo, Chuen Ming Shih |
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Rok vydání: | 2012 |
Předmět: |
Male
medicine.medical_specialty Pathology Lung Neoplasms Single-nucleotide polymorphism Adenocarcinoma Biology Polymerase Chain Reaction Polymorphism Single Nucleotide Gastroenterology Metastasis Gene Frequency Risk Factors Carcinoma Non-Small-Cell Lung Physiology (medical) Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Hypoxia Lung cancer Allele frequency Alleles Aged Biochemistry (medical) Public Health Environmental and Occupational Health General Medicine Odds ratio Middle Aged Hypoxia-Inducible Factor 1 alpha Subunit Prognosis medicine.disease Squamous carcinoma Genotype frequency Logistic Models Case-Control Studies Carcinoma Squamous Cell Female Polymorphism Restriction Fragment Length |
Zdroj: | Translational Research. 159:42-50 |
ISSN: | 1931-5244 |
Popis: | Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and has been suggested to play an important role in tumorigenesis and metastasis. The aim of this study was to investigate the role of HIF-1α-1772 C/T (P582S) and -1790 G/A (A588T) polymorphisms in the susceptibility to and severity of non-small-cell lung cancer (NSCLC). Using a case-control study design and polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) analysis, the allele frequencies and genotype distributions of each single nucleotide polymorphism in 285 NSCLC cases and 300 gender-matched controls were compared. The distribution of the genotype frequencies of HIF-1α-1772 C/T and -1790 G/A were significantly different between the NSCLC and the controls. Logistic regression analysis revealed that higher odds ratios (ORs) for lung cancer were observed for individuals with HIF-1α-1772 T/T genotype against CC/CT genotypes (an OR of 4.04, 95% confidence interval [CI] = 2.02-8.08, P = 0.0001), and HIF-1α-1790 A/A genotype against GG/GA genotypes (an OR of 4.42, 95% CI 2.22-8.78, P0.0001). There were no relationship between HIF-1α-1772 C/T or -1790 G/A allele distribution and disease severity of NSCLC (P0.05). However, those patients carrying a HIF-1α-1772 T/T genotype or a HIF-1α-1790 A/A had a tendency toward inferior prognosis compared with other patients. |
Databáze: | OpenAIRE |
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