Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease
Autor: | Ling Zhang, Jiali Pu, Heng Zhang, Binggui Sun, Tingting Zheng, Baorong Zhang, Yanxing Chen, H.G. Pan, Zhangyu Guo, Yan-Fang Mao |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cognitive Neuroscience Hippocampus microglia β-amyloid plaques Disease exosomes Exosome 03 medical and health sciences 0302 clinical medicine Medicine Original Research Microglia business.industry Dentate gyrus aging Extracellular vesicle Microvesicles Cortex (botany) Cell biology 030104 developmental biology medicine.anatomical_structure nervous system business Neuroscience Alzheimer’s disease 030217 neurology & neurosurgery |
Zdroj: | Frontiers in Aging Neuroscience |
ISSN: | 1663-4365 |
Popis: | Exosomes, a type of extracellular vesicle, have been shown to be involved in many disorders, including Alzheimer's disease (AD). Exosomes may contribute to the spread of misfolded proteins such as amyloid-β (Aβ) and α-synuclein. However, the specific diffusion process of exosomes and their final destination in brain are still unclear. In the present study, we isolated exosomes from peripheral plasma and injected them into the hippocampus of an AD mouse model, and investigated exosome diffusion. We found that injected exosomes can spread from the dentate gyrus (DG) to other regions of hippocampus and to the cortex. Exosomes targeted microglia preferentially; this phenomenon is stable and is not affected by age. In AD mice, microglia take up lower levels of exosomes. More interestingly, plasma exosomes cluster around the Aβ plaques and are engulfed by activated microglia nearby. Our data indicate that exosomes can diffuse throughout the brain and may play a role in the dynamics of amyloid deposition in AD through microglia. |
Databáze: | OpenAIRE |
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