Psychiatric Disorders in Children and Adolescents With Psychogenic Nonepileptic Seizures
| Autor: | René Ernst Nielsen, Maria Rodrigo-Domingo, Jakob Christensen, Ann Eva Christensen, Anne Sofie Hansen, Charlotte Ulrikka Rask |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Parents medicine.medical_specialty Adolescent Denmark Dissociative Disorders Risk Assessment Cohort Studies 03 medical and health sciences Epilepsy 0302 clinical medicine International Classification of Diseases Seizures medicine Prevalence Psychogenic disease Humans 030212 general & internal medicine Affective Symptoms Registries Psychiatry Child business.industry Incidence (epidemiology) Incidence Mental Disorders Confounding Electroencephalography medicine.disease Confidence interval Psychological evaluation Relative risk Child Preschool Female Neurology (clinical) business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Hansen, A S, Rask, C U, Christensen, A-E, Rodrigo-Domingo, M, Christensen, J & Nielsen, R E 2021, ' Psychiatric Disorders in Children and Adolescents With Psychogenic Nonepileptic Seizures ', Neurology, vol. 97, no. 5, pp. e464-e475 . https://doi.org/10.1212/WNL.0000000000012270 Hansen, A S, Rask, C U, Christensen, A E, Rodrigo-Domingo, M, Christensen, J & Nielsen, R E 2021, ' Psychiatric Disorders in Children and Adolescents With Psychogenic Nonepileptic Seizures ', Neurology, vol. 97, no. 5, pp. e464-e475 . https://doi.org/10.1212/WNL.0000000000012270 |
| Popis: | ObjectiveKnowledge regarding psychiatric disorders in children and adolescents with psychogenic nonepileptic seizures (PNES) is limited. This study outlines the spectrum and risk of psychiatric disorders in childhood-onset PNES.MethodsWe performed a nationwide matched cohort study of children and adolescents with PNES 5 to 17 years of age at the time of diagnosis between January 1, 1996, and December 31, 2014. Two matched comparison groups were included: children and adolescents with epilepsy (ES) and children and adolescents without PNES or epilepsy, called healthy controls (HC). Outcomes were prevalent psychiatric disorders before index (i.e., date of diagnosis or corresponding date for HC) and incident psychiatric disorders 2 years after index. Relative risks (RRs) were calculated and adjusted for potential confounders.ResultsWe included 384 children and adolescents with validated PNES, 1,152 with ES, and 1,920 HC. Among the cases of PNES, 153 (39.8%) had prevalent psychiatric disorders and 150 (39.1%) had incident psychiatric disorders. Compared to the ES and HC groups, children and adolescents with PNES had elevated risks of both prevalent psychiatric disorders (adjusted RRPNES/ES 1.87, 95% confidence interval [CI] 1.59–2.21, adjusted RRPNES/HC 5.54, 95% CI 4.50–6.81) and incident psychiatric disorders (adjusted RRPNES/ES 2.33, 95% CI 1.92–2.83, adjusted RRPNES/HC 8.37, 95% CI 6.31–11.11). A wide spectrum of specific psychiatric disorders displayed elevated RRs.ConclusionsChildren and adolescents with PNES are at higher risk of a wide range of psychiatric disorders compared to children and adolescents with ES and HC. A careful psychiatric evaluation is warranted to optimize and individualize treatment. |
| Databáze: | OpenAIRE |
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